Pontus Skoglund's Ancient Genomics Lab at the Francis Crick Institute in London is looking for a postdoctoral fellow interested in proteomic approaches to human origins. The Skoglund Ancient Genomics lab is a dynamic team with backgrounds in computational biology, molecular biology and archaeology, with state-of-the-art computational infrastructure and an ancient DNA clean room facility. The Francis Crick Institute is the largest biomedical institute under one roof in Europe. The Institute is located next to King’s Cross in central London, with excellent transport links to greater London and Cambridge. Ancient genome sequencing has revolutionised our understanding of the evolutionary history of modern humans and close relatives such as Neandertals. However, in most environments DNA may only be retrieved from a few thousand years ago. In contrast, proteins degrade more slowly than DNA, and may thus allow insights from deeper time. However, the number of evolutionarily informative variants is lower in ancient proteomic data, and authentication methods for ancient proteomics are in their infancy compared to methods for ancient DNA. This postdoc fellow will join Pontus Skoglund and the Crick Ancient Genomics laboratory in applying and developing proteomic approaches to extend our understanding of human evolution. The work will include improving and developing methods for bioinformatic retrieval, authentication, and reconstruction of ancient protein sequences from extinct populations in collaboration with proteomics experts at the Francis Crick Institute and international collaborators. Then adapting population genetic and phylogenetic approaches (f-statistics & admixture graphs), and applying the methods to data from fossil material supported by the ancient DNA facility.
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[Website The Francis Crick Institute]